Replication of avian influenza viruses in humans
Identifieur interne : 002048 ( Main/Exploration ); précédent : 002047; suivant : 002049Replication of avian influenza viruses in humans
Auteurs : A. S. Beare [Royaume-Uni] ; R. G. Webster [États-Unis]Source :
- Archives of Virology [ 0304-8608 ] ; 1991-03-01.
English descriptors
- Teeft :
- Antibody responses, Avian, Avian influenza, Avian influenza viruses, Avian strains, Beare, Clinical reactions, Dos, Harvard hospital, Hemagglutinin, High doses, Hinshaw, Human influenza, Human strains, Human viruses, Human volunteers, Influenza, Influenza viruses, Inoculated, Jude research hospital, Molecular biology, Nasal washings, Pandemic influenza, Present studies, Receptor specificity, Replication, Serological studies, Southern china, Squirrel monkeys, Subtypes, Surface antigens, Virol, Virology, Virus, Virus excretions, Volunteers inoculated, Wild ducks.
Abstract
Summary: Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1–14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses.
Url:
DOI: 10.1007/BF01314321
Affiliations:
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S." last="Beare">A. S. Beare</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Research Centre, Harvard Hospital, Salisbury, Wiltshire</wicri:regionArea><wicri:noRegion>Wiltshire</wicri:noRegion></affiliation></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1991-03-01">1991-03-01</date><biblScope unit="volume">119</biblScope><biblScope unit="issue">1-2</biblScope><biblScope unit="page" from="37">37</biblScope><biblScope unit="page" to="42">42</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody responses</term><term>Avian</term><term>Avian influenza</term><term>Avian influenza viruses</term><term>Avian strains</term><term>Beare</term><term>Clinical reactions</term><term>Dos</term><term>Harvard hospital</term><term>Hemagglutinin</term><term>High doses</term><term>Hinshaw</term><term>Human influenza</term><term>Human strains</term><term>Human viruses</term><term>Human volunteers</term><term>Influenza</term><term>Influenza viruses</term><term>Inoculated</term><term>Jude research hospital</term><term>Molecular biology</term><term>Nasal washings</term><term>Pandemic influenza</term><term>Present studies</term><term>Receptor specificity</term><term>Replication</term><term>Serological studies</term><term>Southern china</term><term>Squirrel monkeys</term><term>Subtypes</term><term>Surface antigens</term><term>Virol</term><term>Virology</term><term>Virus</term><term>Virus excretions</term><term>Volunteers inoculated</term><term>Wild ducks</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1–14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Beare, A S" sort="Beare, A S" uniqKey="Beare A" first="A. S." last="Beare">A. S. Beare</name></noRegion></country><country name="États-Unis"><region name="Tennessee"><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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